Mark Kotter

Tau aggregate replication occurs at the pre-synapse of cultured human neurons and increases with application of TNFa

The paper shows TNFα promotes tau aggregation at pre-synapses in human neurons, forming non-fibrillar aggregates that replicate rapidly.

imAgeScore, a Cell Painting-Based Predictor of Cellular Age for High-throughput Drug Screening Applications

imAgeScore predicts cellular age using Cell Painting features, identifies age-modulating compounds, and validates rejuvenation effects in human fibroblasts.

Assessing the impact of mono- and bi-allelic deletions in NRXN1 on synaptic function

This study compares mono- and bi-allelic NRXN1 mutations in iPSC-derived neurons, showing bi-allelic mutations cause more severe molecular, synaptic, and functional impairments.

Drug treatment alters performance in a neural microphysiological system of information processing

The paper tests anti-seizure drugs on a synthetic neural system and finds carbamazepine improves gameplay metrics, linking glutamatergic inhibition to enhanced performance.

Circadian clocks in human cerebral organoids

This study demonstrates circadian rhythms in human brain cells and organoids, showing they are temperature-compensated and modulated by drugs and cortisol, with implications for chronobiology and brain health.

Energetic substrate availability regulates synchronous activity in an excitatory neural network

The paper investigates how glucose availability affects synchronous activity in excitatory neural networks and finds that glucose is essential for sustaining high-frequency bursting, while lactate and pyruvate cannot substitute.