Nicholas J. F. Gatford

This study compares mono- and bi-allelic NRXN1 mutations in iPSC-derived neurons, showing bi-allelic mutations cause more severe molecular, synaptic, and functional impairments.

This study investigates the impact of NRXN1 intronic deletions on early cortical development using hiPSCs, finding altered isoform expression and dendritic morphology.

This study shows that NLGN3/4X clustering at growth cones promotes neuritogenesis and actin organization in immature human neurons, with ASD-associated variants lacking these effects.

This study shows ZNF804A and NT5C2 interact at synapses in cortical neurons, suggesting they function as a complex in schizophrenia risk.

This study shows that estradiol restores dendritic spine density in a cellular model of schizophrenia and depression by modulating DISC1 function and synaptic protein distribution.