Structural mechanism of the type IX Retron-Kva2 anti-phage defense system
Yuya Hayashi, Yoshihisa Mitsuda, Kotaro Chihara, Kanta Yoneyama, Junichiro Ishikawa, Masahiro Hiraizumi, Masanori Hashino, Kazuhiro Horiba, Keitaro Yamashita, Kotaro Kiga, Hiroshi Nishimasu
This study reveals the structural mechanism of the type IX Retron-Kva2 anti-phage defense system in Klebsiella variicola, showing how it cleaves host RNAs to inhibit phage infection.
bioRxiv · Jul 15, 2026 · PreprintBiochemistry