Sox2 modulation increases naive pluripotency plasticity
Kathryn Tremble, Giuliano Giuseppe Stirparo, Lawrence E. Bates, Katsiaryna Maskalenka, Hannah T. Stuart, Kenneth Jones, Amanda Andersson-Rolf, Aliaksandra Radzisheuskaya, Bon‐Kyoung Koo, Paul Bertone, José Silva
This study shows that low Sox2 expression in naive pluripotent stem cells enhances their developmental plasticity without impairing neuroectoderm differentiation.
iScience · Feb 7, 2021Peer-reviewedDevelopmental Biology