Lawrence E. Bates

Array-CNCC: precise aggregation and arrayed plating facilitate quantitative phenotyping of human cranial neural crest cells and craniofacial disease modelling

Protein-protein interactions drive differences in the spatiotemporal dynamics of transcription factors NANOG and SOX2 in naïve pluripotent cells

The paper tracks SOX2 and NANOG dynamics in live cells using advanced microscopy and analysis pipelines, revealing differences in their spatiotemporal behavior due to protein-protein interactions.

WNT-mediating TCF/LEF transcription factor gene expression in early human pluripotency and cell lineages differs from the rodent paradigm

The paper compares WNT/{beta}-catenin signalling and TCF/LEF gene expression in human and mouse pluripotent stem cells, revealing species-specific differences in early development.

A new resource of clonal pluripotent human stem cell lines exhibiting inter- and intra-embryo consistency and variability

The paper describes a resource of clonal human pluripotent stem cell lines derived from embryos, showing intra- and inter-embryo variation and potential for modeling chromosomal mosaicism.

OCT4 activates a Suv39h1-repressive antisense lncRNA to couple histone H3 Lysine 9 methylation to pluripotency

The paper identifies a genetic circuitry where OCT4 activates an antisense lncRNA that represses Suv39h1, linking H3K9 methylation levels to pluripotency in mouse ES cells.

Auxin-degron system identifies immediate mechanisms of Oct4

This study uses an auxin-degron system to show that Oct4 depletion reduces pluripotency factor expression and enhances Nanog genome binding while decreasing H3K27ac marks.

Sox2 modulation increases naive pluripotency plasticity

This study shows that low Sox2 expression in naive pluripotent stem cells enhances their developmental plasticity without impairing neuroectoderm differentiation.

Oct4 regulates embryonic pluripotency via metabolic mechanisms and Stat3 signalling.

This study identifies OCT4's role in maintaining pluripotency through metabolic regulation and Stat3 signaling in mouse embryos.