Author

Madhavan S. Venkatesh

Gladstone InstitutesORCID 0000-0002-2698-367XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Organism:human· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Approach:machine learning (classical)· 1 Organism:mouse· 1 Assay:organoid / primary culture· 1

Frequent Co-Authors

Christina V. TheodorisiD· 2 shared Brendan Griffen· 1 shared David A. ElliottiD· 1 shared Drew M. TitmarshiD· 1 shared Ellen B. Keen· 1 shared Enzo R. PorrelloiD· 1 shared Han CheniD· 1 shared Hannah HuckstepiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersPhysiology

Christina V. TheodorisORCID

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2 papers

Recent·Most cited

Alpha Protein Kinase 3 Gene Therapy Restores Heart Function in Mouse and Human Models of Cardiomyopathy

James W. McNamara, Ellen B. Keen, Rebecca Sutton, Yinghan She, Hannah Huckstep, Lina H.H. Le, Neda R. Mehdiabadi, Madhavan S. Venkatesh, Brendan Griffen, Richard J. Mills, Christina V. Theodoris, James E. Hudson, Drew M. Titmarsh, Sean J. Humphrey, Enzo R. Porrello, David A. Elliott

This study shows that gene therapy with AAV-ALPK3 improves heart function in mouse and human models of cardiomyopathy caused by ALPK3 variants.

Nature Cardiovascular Research · Aug 19, 2026Peer-reviewedPhysiology

Quantized multi-task learning for context-specific representations of gene network dynamics

Han Chen, Madhavan S. Venkatesh, Javier Gómez Ortega, Siddharth V Mahesh, Tarak Nandi, Ravi Madduri, Karin Pelka, Christina V. Theodoris

The paper develops a multi-task learning approach to create context-specific gene network representations, applying it to colorectal tumors to predict therapeutic targets.

bioRxiv · Aug 16, 2024 · PreprintBioinformatics