Christina V. Theodoris

This study shows that gene therapy with AAV-ALPK3 improves heart function in mouse and human models of cardiomyopathy caused by ALPK3 variants.

This study uses proteomics to identify a cryptic JPH2 loss-of-function in a paediatric DCM patient, revealing a novel mechanism of recessive disease.

The paper introduces a temporal AI model, MaxToki, trained on extensive gene data to predict cell state changes across human aging and identifies age-modulating targets.

This study identifies soluble DLK1 from senescent microglia as a factor impairing oligodendrocyte function and altering neuronal activity in aging.

The paper develops a multi-task learning approach to create context-specific gene network representations, applying it to colorectal tumors to predict therapeutic targets.

The paper applies transfer learning to predict network biology features across different biological contexts.

MIRA jointly models gene expression and chromatin accessibility in single cells to infer regulatory circuits and lineage trees during development.