Michael S. Sacks

This study shows that vascular network formation by hiPSC-derived endothelial progenitors in 3D hydrogels depends on matrix stiffness, contractility, and cell-induced remodeling, not just mechanotransduction.

This paper uses 3D microscale mechanical simulations to predict bulk mechanical properties of hydrogel-coated electrospun meshes, revealing non-affine deformations and stress-strain differences.