Tong Chen

This paper introduces PepRePs, a system using peptide-retargeted phosphatases to selectively manipulate protein phosphorylation, showing reduced phosphorylation and downstream effects on cellular processes.

This paper presents a high-throughput platform for screening peptide-guided protein degraders in mammalian cells, demonstrating their ability to reduce target protein abundance and function.

PeptiVerse provides a unified platform for predicting therapeutic peptide properties using both amino acid sequences and SMILES-based representations, supporting early-stage development and generative design.

This paper introduces PTM-Mamba, a protein language model that incorporates PTM tokens and Mamba blocks to improve performance on PTM-specific tasks.

moPPIt generates motif-specific and functionally active peptide binders using sequence data, validated in vitro and in disease-relevant assays.