Lauren Hong

PepRePs: Peptide-Retargeted Phosphatases Designed with Generative Language Models

This paper introduces PepRePs, a system using peptide-retargeted phosphatases to selectively manipulate protein phosphorylation, showing reduced phosphorylation and downstream effects on cellular processes.

Programmable protein degraders enable selective knockdown of pathogenic β-catenin subpopulations in vitro and in vivo

This paper develops programmable protein degraders (uAbs) that selectively knock down pathogenic β-catenin in vitro and in vivo, reducing tumor cell survival and proliferation.

A Mammalian High-Throughput Screen for AI-Designed Peptide-Guided Protein Degraders

This paper presents a high-throughput platform for screening peptide-guided protein degraders in mammalian cells, demonstrating their ability to reduce target protein abundance and function.

PIC recruitment by synthetic reader-actuators to polycomb-silenced genes blocks triple-negative breast cancer invasion

The paper develops a synthetic reader-actuator to activate silenced tumor suppressor genes in triple-negative breast cancer cells, reducing invasion and promoting apoptosis.