Cell BiologyEndocrinologyPeer-reviewed
Cholesterol Metabolite 27-Hydroxycholesterol Enhances the Secretion of Cancer Promoting Extracellular Vesicles by a Mitochondrial ROS-Induced Impairment of Lysosomal Function
Anasuya Das Gupta, Jaena Park, Janet Elise Sorrells…·Erik Russell Nelson
This study shows that 27-hydroxycholesterol increases EV secretion by impairing lysosomal function through mitochondrial ROS, and antioxidant treatment reverses this effect.
11 citations