This study investigates the role of the CHCHD2-CHCHD10 protein complex in mitochondrial dysfunction and lipid homeostasis in mice, showing its importance in motor function and disease resistance.

Cell Death and Disease · Oct 6, 2025Peer-reviewedNeuroscience

An epigenetically distinct HSC subset supports thymic reconstitution

Harold Kunal Elias, Sneha Mitra, Marina Burgos da Silva, Adhithi Rajagopalan, Brianna Gipson, Nicole MynYi Lee, Anastasia I. Kousa, Mohamed Ashraf Ali, Simon A. Grassmann, Rhoshini Raghuraman, Xiaoqun Zhang, Susan DeWolf, Melody M. Smith, Hana Andrlová, Kimon V. Argyropoulos, , Marcel R.M. van den Brink

This study identifies an epigenetically distinct HSC subset, Kitlo, that supports better thymic and T-cell reconstitution in mice and humans.

Nature Communications · Jul 4, 2025Peer-reviewedImmunology

Spatial Multimodal Analysis of Transcriptomes and Metabolomes in Tissues

Marco Vicari, Reza Mirzazadeh, Anna Nilsson, Mohammadreza Shariatgorji, Patrik Bjärterot, Ludvig Larsson, Hower Lee, Mats F. Nilsson, Julia Foyer, Markus Ekvall, Paulo Czarnewski, Xiaoqun Zhang, Per Svenningsson, Lukas Käll, Per E. Andrén, Joakim Lundeberg

This paper introduces a spatial multimodal analysis method that integrates histology, mass spectrometry imaging, and spatial transcriptomics to study mRNA and metabolite distributions in brain tissues.

Nature Biotechnology · Sep 4, 2023Peer-reviewedGenomics