This study investigates the role of the CHCHD2-CHCHD10 protein complex in mitochondrial dysfunction and lipid homeostasis in mice, showing its importance in motor function and disease resistance.

Cell Death and Disease · Oct 6, 2025Peer-reviewedNeuroscience

The mitochondrial mRNA stabilizing protein, SLIRP, regulates skeletal muscle mitochondrial structure and respiration by exercise-recoverable mechanisms

Tang Cam Phung Pham, Steffen Henning Raun, Essi Havula, Carlos Henríquez‐Olguín, Diana Rubalcava-Gracia, Emma Frank, Andreas Mæchel Fritzen, Paulo R. Jannig, Nicoline R. Andersen, Rikke Kruse, Mona Sadek Ali, Andrea Irazoki, Jens Frey Halling, Stine Ringholm, Elise J. Needham, , Lykke Sylow

This study identifies SLIRP as a mitochondrial mRNA stabilizing protein that regulates mitochondrial structure and respiration in skeletal muscle, with exercise improving mitochondrial function through increased mitoribosome capacity.

Nature Communications · Nov 13, 2024Peer-reviewedMolecular Biology

A role for BCL2L13 and autophagy in germline purifying selection of mtDNA

Laura Sophie Kremer, Lyuba V. Bozhilova, Diana Rubalcava-Gracia, Roberta Filograna, Mamta Upadhyay, Camilla Koolmeister, Patrick Francis Chinnery, Nils‐Göran Larsson

This study investigates the role of BCL2L13 and autophagy in mtDNA purifying selection by analyzing knockout models in mice.

PLoS Genetics · Jan 6, 2023Peer-reviewedGenetics