Yang Zhang

This study identifies potential intermediate hosts of SARS-CoV-2 by modeling Spike-RBD binding affinity to ACE2 proteins across multiple species.

The paper designs peptides to block SARS-CoV-2 spike protein binding to hACE2 using computational methods, showing improved binding affinity compared to wild-type.

The paper re-analyzes computational findings from two studies, concluding that snakes are not intermediate hosts of 2019-nCoV and that spike protein insertions are naturally evolved from bat coronaviruses.

This study uses multilayered N-glycoproteomics to show impaired N-glycosylation in Alzheimer's disease mouse models, affecting protein function and neuronal health.

The paper reports results from the CAFA3 challenge, showing improved computational protein function prediction and new annotations for over 1000 genes through experimental screens in C. albicans, P. aureginosa, and Drosophila.

This paper develops a probabilistic method to model functional relationships at the splice isoform level by integrating heterogeneous genomic data in mice, revealing isoform-specific interactions and functional diversity.