Nozomi Takahashi

This study identifies ZFP57 as a regulator of postnatal growth and lifelong health by influencing mammary gland function and lactation, with effects on offspring metabolic syndrome.

The paper measures mitotic DNA methylation inheritance at single CpG sites and finds that intermediate methylation is imprecise due to DNMT1 activity, challenging the stability of DNA methylation as an epigenetic mark.

The paper identifies a spontaneously formed retrotransposon variant in mice that exhibits distinct epigenetic marks and is associated with metabolic and gene expression changes.

The paper investigates the relationship between subnuclear localization and gene expression at the imprinted Dlk1-Dio3 locus, finding that transcriptional activity, not repression or parental origin, determines localization.

The paper investigates ZFP57's role in epigenetic regulation, showing it maintains DNA methylation and repressive marks at imprinted regions but is not essential for silencing transposable elements.