Benjamin B. Scott

Diurnal rhythms of choice: a novel state-dependent drift diffusion model uncovers time-dependent changes in rat decision making

This paper introduces a drift diffusion model with hidden Markov states to analyze time-dependent decision-making in rats, revealing daily fluctuations in performance linked to circadian rhythms.

Songbird connectome reveals tunneling of migratory neurons in the adult striatum

The paper uses connectomics to show that migrating neurons in the adult zebra finch striatum physically reshape mature circuits by creating tunnels through synapse-rich regions.

Regulation of Decision Threshold by the Locus Coeruleus

This study shows that locus coeruleus norepinephrine increases decision thresholds, reaction time, and accuracy, and that this effect is mediated by 2 adrenergic receptors.

Psychedelics Relax Priors and Reshape Orbitofrontal Dynamics

This study tests the REBUS model of psychedelics by showing they slow decision times, improve accuracy, and reduce top-down influence in mice.

A State-Dependent Drift Diffusion Model Reveals Mice Actively Explore A Speed-Accuracy Continuum During Decision-Making

The paper introduces a state-dependent drift diffusion model to show mice switch between impulsive and deliberative decision states during tasks, revealing active exploration of the speed-accuracy trade-off.

Altered perceptual integration and learning in autism revealed by games inspired by rodent operant tasks

This study uses a video game inspired by rodent operant tasks to reveal altered perceptual integration and learning in autism, finding slower learning and increased noise in higher-order visual processing.

Three-photon population imaging of subcortical brain regions

The paper introduces a LIFT microscope for three-photon imaging with a large field of view, enabling high-resolution calcium imaging in deep brain regions of mice and rats.

Ramping dynamics in the frontal cortex unfold over multiple timescales during motor planning

The paper analyzes frontal motor cortex activity during motor planning and finds that neural activity unfolds over multiple timescales, supporting a shared mechanism for temporal information processing.

Magnetic voluntary head-fixation in transgenic rats enables lifetime imaging of hippocampal neurons

The paper introduces a magnetic voluntary head-fixation system for longitudinal imaging of hippocampal neurons in transgenic rats.

A cross-species framework for investigating perceptual evidence accumulation

This paper develops a cross-species evidence accumulation task to compare perceptual decision-making in humans, rats, and mice, finding similar strategies but species-specific priorities in speed, accuracy, and reward optimization.

CA1 Engram Cell Dynamics Before and After Learning

This study tracks CA1 engram cell dynamics before and after learning, showing they are influenced by intrinsic activity, behavior, and memory.

In vivo imaging in transgenic songbirds reveals superdiffusive neuron migration in the adult brain

The paper uses in vivo two-photon imaging in transgenic songbirds to show that adult neuron migration follows a superdiffusive model, which can explain the dispersion of new neurons in the HVC.

A miniature kinematic coupling device for mouse head fixation

This paper develops a miniature kinematic coupling device for mice to enable precise repositioning during chronic neuroscience experiments.

GraFT: Graph Filtered Temporal Dictionary Learning for Functional Neural Imaging

GraFT isolates fluorescing components in neural imaging by learning time traces with spatial maps as coefficients, using a graph filtering model based on temporal activity rather than spatial proximity.