Jackie Schiller

BIOPHYSICAL MECHANISMS UNDERLYING THE GENERATION AND MAINTENANCE OF RULE-LEARNING ENGRAM

The paper shows that rule-learning in rodents occurs abruptly through a discrete moment involving enhanced intrinsic excitability, synaptic changes, and a decline in IEG-expressing neurons.

Epigenetic inheritance of complex learning abilities in the mammalian brain

This study shows that complex learning abilities can be inherited through epigenetic modifications in the mammalian brain, as offspring of trained rodents exhibit enhanced neuronal excitability and DNA methylation changes.

Dendritic computation for rule-based flexible categorization

The paper shows that dendritic computation in ET cortical neurons enables rule-dependent flexible categorization by integrating sensory input and inferred task rules.

VTA projections to M1 are essential for reorganization of layer 2-3 network dynamics underlying motor learning

This study shows that VTA dopaminergic inputs to M1 are essential for reorganizing layer 2-3 network dynamics during motor learning.

A novel polycistronic method tailored for engineering split GECIs

The paper demonstrates a method using stop-codons to enable polycistronic expression in eukaryotic cells, leading to the development of split-GECIs for monitoring cellular processes.

GraFT: Graph Filtered Temporal Dictionary Learning for Functional Neural Imaging

GraFT isolates fluorescing components in neural imaging by learning time traces with spatial maps as coefficients, using a graph filtering model based on temporal activity rather than spatial proximity.

Plasticity of olfactory bulb inputs mediated by dendritic NMDA-spikes in piriform cortex

The paper shows that LOT synapses in piriform cortex undergo LTP via local NMDA-spikes, while IC synapses use STDP, suggesting branch-specific memory formation for odor information.

Cell-type specific outcome representation in primary motor cortex

The paper identifies layer-specific outcome signals in mouse motor cortex that support reinforcement learning of skilled movements.

Stimjim: open source hardware for precise electrical stimulation

Stimjim is an open-source, low-cost electrical stimulation device that provides precise microsecond control for in vitro and in vivo experiments.

NMDA spikes mediate amplification of odor pathway information in the piriform cortex

This study shows that NMDA spikes in piriform cortex pyramidal neurons amplify and selectively combine olfactory bulb inputs, explaining nonlinear odor code transformation.

Automated cellular structure extraction in biological images with applications to calcium imaging data

The paper introduces a method for extracting cellular structures and denoising temporal signals in calcium imaging data using graph-based clustering and nonlinear mapping.