Jerome C. Mertz

Subthreshold membrane depolarization powerfully engages intracellular calcium dynamics in the awake mammalian brain

The paper investigates how subthreshold membrane depolarization influences intracellular calcium dynamics in awake mice, showing strong coupling during prolonged depolarization and weaker coupling during isolated spikes.

Relative phase of membrane potential theta oscillations between individual hippocampal neurons code space

The paper analyzes the relative phase of membrane potential theta oscillations between hippocampal neurons during a virtual spatial task, revealing spatially coded phase shifts independent of spiking activity.

Superresolution imaging of live samples by centroid reassignment microscopy

This paper introduces a superresolution microscopy technique called centroid reassignment microscopy (CRM) that enables fast, robust, and protocol-compatible imaging of live samples.

Ultrasensitive in vivo infrared spectroscopic imaging via oblique photothermal microscopy

This paper introduces an oblique photothermal microscope (OPTM) for ultrasensitive in vivo IR spectroscopic imaging with sub-micron resolution, enabling low-dose imaging of skin and tracking of topical drugs.

Three-photon population imaging of subcortical brain regions

The paper introduces a LIFT microscope for three-photon imaging with a large field of view, enabling high-resolution calcium imaging in deep brain regions of mice and rats.

Large-scale deep tissue voltage imaging with targeted illumination confocal microscopy

This paper introduces a microscope combining targeted illumination and confocal gating to improve voltage imaging in dense tissues, enhancing signal-to-noise ratio and reducing crosstalk.

Multiplane HiLo microscopy with speckle illumination and non-local means denoising

This paper introduces a method to reduce speckle noise in multiplane HiLo microscopy using non-local means denoising, enabling fast, high-contrast volumetric imaging.

Sensitivity optimization of a rhodopsin-based fluorescent voltage indicator

The paper identifies a mutation that enhances the sensitivity of a fluorescent voltage indicator, improving its ability to detect both spiking and subthreshold voltage signals in multiple organisms.

Single and complex spikes relay distinct frequency-dependent circuit information in the hippocampus

The paper shows that single and complex spikes in hippocampal neurons encode frequency-specific information during spatial navigation, with distinct roles for theta and gamma rhythms.

High-speed, multi-Z confocal microscopy for voltage imaging in densely labeled neuronal populations

The paper develops a high-speed, multi-Z confocal microscope to improve voltage imaging in densely labeled neuronal populations by increasing contrast and speed.

Large-scale voltage imaging in the brain using targeted illumination

This paper demonstrates targeted illumination with SomArchon to enable large-scale voltage imaging in the brain, improving signal contrast and reducing background contamination.