Antibody feedback establishes an affinity brake in the germinal center
Yu Yan, Xuesong Wang, Zhenfei Xie, Daniel L. V. Bader, Ryan H. Lim, Krystal M. Ma, Christopher A. Cottrell, Jon M. Steichen, Liling Xu, Paula Maldonado Villavicencio, Madhav Akauliya, Ja‐Hyun Koo, Jacqueline Ming Shen, Alexandra Vernich, Oleksandr Kalyuzhniy, , Facundo D. Batista
The paper investigates how B cell affinity affects germinal center (GC) responses by showing high-affinity B cells have shorter GC residence times and lower-affinity B cells are maintained, suggesting an antibody feedback mechanism that modulates affinity and epitope spreading.
bioRxiv · Nov 13, 2025 · PreprintImmunology