Zhenfei Xie

This study shows that mRNA vaccines can prime and mature ultrarare HIV bnAb precursor B cells in NHPs, with improved affinity using a modified immunogen.

The paper investigates how B cell affinity affects germinal center (GC) responses by showing high-affinity B cells have shorter GC residence times and lower-affinity B cells are maintained, suggesting an antibody feedback mechanism that modulates affinity and epitope spreading.

The paper shows that DPPA2 and DPPA4 are not required for zygotic genome activation or preimplantation development in mouse embryos, contrasting their role in ESCs.

This study shows that reduced gene dosage in multiple genes causes multisystem disorders in DM1 by creating mouse models with multigene mutations.