Author
Harvard UniversityORCID 0000-0002-1130-9463Unclaimed ORCID profile · follow to get notified of new preprints
8 papers
Recent·Most cited
Paula Maldonado Villavicencio, Maria Bottermann, Myriam Ortiz Isuiza, Shivang Parikh, John E. Warner, Anthony Alicea, Elizabeth Zhou, Thavaleak Prum, Hannah Naili, Xiao Liu, Stephanie R. Weldon, Facundo D. Batista
The paper identifies a GC-independent memory B cell subset derived from B1 cells that contributes to protective immunity against viral infection.
bioRxiv · Jul 25, 2026 · PreprintImmunology
Prabhanshu Tripathi, Ja‐Hyun Koo, Xuejun Chen, Lais Da Silva Pereira, Marlon Dillon, Baoshan Zhang, Mariah Lofgren, Katelyn T. Nguyen, I‐Ting Teng, Brian G. Bonilla, Sarah Kerscher, Wing‐Pui Kong, Amy R. Henry, Tyler Stephens, Yaroslav Tsybovsky, , Tongqing Zhou
This paper develops a nanoparticle-based junctional vaccine targeting PfCSP and compares its efficacy to the R21 vaccine in reducing malaria liver burden in mice.
npj Vaccines · Apr 27, 2026Peer-reviewedImmunology
Nitesh Mishra, Bo Liang, Ryan S. Roark, Amrit Raj Ghosh, Sean Callaghan, Wen-Hsin Lee, Xuduo Li, Anh L. Vo, Gabriel Avillion, Rohan Roy Chowdhury, Rumi Habib, Frédéric Bibollet‐Ruche, Gabriella Giese, Prabhgun Oberoi, Khaled Amereh, , Raiees Andrabi
This study shows that a germline-targeting HIV immunogen induces cross-neutralizing antibodies in outbred macaques by priming V2-apex bnAb B cell precursors.
Immunity · Apr 1, 2026Peer-reviewedImmunology
Yu Yan, Xuesong Wang, Zhenfei Xie, Daniel L. V. Bader, Ryan H. Lim, Krystal M. Ma, Christopher A. Cottrell, Jon M. Steichen, Liling Xu, Paula Maldonado Villavicencio, Madhav Akauliya, Ja‐Hyun Koo, Jacqueline Ming Shen, Alexandra Vernich, Oleksandr Kalyuzhniy, , Facundo D. Batista
The paper investigates how B cell affinity affects germinal center (GC) responses by showing high-affinity B cells have shorter GC residence times and lower-affinity B cells are maintained, suggesting an antibody feedback mechanism that modulates affinity and epitope spreading.
bioRxiv · Nov 13, 2025 · PreprintImmunology
Gordon A. Dale, Bingxian Chen, Ja‐Hyun Koo, Martina Wecera, Sven Kratochvil, Facundo D. Batista
The paper develops a computational metric from protein structures to predict high-affinity malaria antibodies, demonstrating its effectiveness with two PfCSP-targeting antibodies.
bioRxiv · Sep 30, 2025 · PreprintImmunology
James A. Ferguson, Sai Sundar Rajan Raghavan, Garazi Peña Alzua, Disha Bhavsar, Jiachen Huang, Alesandra J. Rodriguez, Jonathan L. Torres, Maria Bottermann, Julianna Han, Florian Krammer, Facundo D. Batista, Andrew B. Ward
This paper develops a method to discover monoclonal antibodies directly from immune sera using cryoEM and computational tools, significantly speeding up the process and improving accuracy.
Science Advances · Aug 15, 2025Peer-reviewedImmunology
Amrit Raj Ghosh, Rumi Habib, Nitesh Mishra, Ryan S. Roark, Madhav Akauliya, Ali A. Albowaidey, Joel D. Allen, Khaled Amereh, Gabriel Avillion, Maria Bottermann, Bo Liang, Namit Chaudhary, Sean Callaghan, Jonathan Dye, Xuduo Li, , Facundo D. Batista
This study shows that a single immunization with a germline-targeting trimer can induce broad HIV-1 neutralizing antibodies in a rhesus macaque bnAb mouse model.
bioRxiv · Jun 12, 2025 · PreprintImmunology
Rumi Habib, Ryan S. Roark, Hui Li, Andrew Jesse Connell, Michael P. Hogarty, Kshitij Wagh, Shuyi Wang, Lorie Marchitto, Ashwin N. Skelly, John W. Carey, Kirsten J. Sowers, Kasirajan Ayyanathan, Samantha J. Plante, Frédéric Bibollet‐Ruche, Young-Hoon Park, , George M. Shaw
The paper identifies B cell priming as the main obstacle to developing HIV-1 V2 apex broadly neutralizing antibodies in SHIV-infected macaques.
bioRxiv · May 3, 2025 · PreprintImmunology