Ja‐Hyun Koo

This paper develops a nanoparticle-based junctional vaccine targeting PfCSP and compares its efficacy to the R21 vaccine in reducing malaria liver burden in mice.

The paper investigates how B cell affinity affects germinal center (GC) responses by showing high-affinity B cells have shorter GC residence times and lower-affinity B cells are maintained, suggesting an antibody feedback mechanism that modulates affinity and epitope spreading.

The paper develops a computational metric from protein structures to predict high-affinity malaria antibodies, demonstrating its effectiveness with two PfCSP-targeting antibodies.