João Botelho

Rsm-mediated post-translational control of the Pseudomonas putida Type VI Secretion System

This study shows that Rsm proteins regulate the K1-T6SS in Pseudomonas putida by repressing translation of T6SS components and effectors, and that their removal enhances T6SS activity and pathogen killing.

Co-evolutionary dynamics of defense systems and anti-defense genes in chromosomes and mobile genetic elements of Enterobacteriaceae

The paper analyzes DEF and anti-DEF gene dynamics across Enterobacteriaceae genomes, finding differences in turnover rates between chromosomal and mobile genetic elements.

Resistance variation and bacterial interactions shape the adaptation of a genetically diverse bacterial population to antimicrobial treatment

This study shows that resistance variation and bacterial interactions influence the adaptation of a genetically diverse Pseudomonas aeruginosa population to antibiotic treatment.

Timescales and genetic linkage explain the variable impact of defense systems on horizontal gene transfer

The paper examines how defense systems affect horizontal gene transfer (HGT) across different timescales and finds that CRISPR-Cas most often reduces MGE abundance and gene acquisition, but this effect is masked by recent co-transfer events.