Author

Nathanial J. Tolman

Pennsylvania State UniversityORCID 0000-0002-2775-780XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:CRISPR screen· 1 Approach:experimental assay· 1 Organism:human· 1 Research Focus:perturbation response prediction· 1

Frequent Co-Authors

Anastasia HaleiD· 1 shared Anchal SharmaiD· 1 shared Ashna DhoonmooniD· 1 shared Claudia M. NicolaeiD· 1 shared Emily M. SchleicheriD· 1 shared George‐Lucian MoldovaniD· 1 shared Hong‐Gang WangiD· 1 shared Kristen E. ClementsiD· 1 shared

Activity by Year

2020-2020 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperMolecular Biology

Anastasia HaleORCID

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1 paper

Recent·Most cited

Identification of regulators of poly-ADP-ribose polymerase (PARP) inhibitor response through complementary CRISPR knockout and activation screens

Kristen E. Clements, Emily M. Schleicher, Tanay Thakar, Anastasia Hale, Ashna Dhoonmoon, Nathanial J. Tolman, Anchal Sharma, Xinwen Liang, Yuka Imamura Kawasawa, Claudia M. Nicolae, Hong‐Gang Wang, Subhajyoti De, George‐Lucian Moldovan

This study identifies genetic regulators of PARP inhibitor response using CRISPR screens, revealing TIP60 as a key factor that reverses PARPi sensitivity in BRCA2-deficient cells.

Nature Communications · Nov 30, 2020Peer-reviewedMolecular Biology