Author

Kristen E. Clements

Pennsylvania State UniversityORCID 0000-0002-6877-3507Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:CRISPR screen· 1 Research Focus:perturbation response prediction· 1

Frequent Co-Authors

Claudia M. NicolaeiD· 2 shared George‐Lucian MoldovaniD· 2 shared Tanay ThakariD· 2 shared Anastasia HaleiD· 1 shared Anchal SharmaiD· 1 shared Anja‐Katrin BielinskyiD· 1 shared Ashna DhoonmooniD· 1 shared Binghui SheniD· 1 shared

Activity by Year

2020-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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2 shared papersMolecular Biology

Claudia M. NicolaeORCID

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2 papers

Recent·Most cited

Molecular BiologyNature CommunicationsPeer-reviewedNov 30, 2020

Identification of regulators of poly-ADP-ribose polymerase (PARP) inhibitor response through complementary CRISPR knockout and activation screens

Kristen E. Clements, Emily M. Schleicher, Tanay Thakar…·George‐Lucian Moldovan

This study identifies genetic regulators of PARP inhibitor response using CRISPR screens, revealing TIP60 as a key factor that reverses PARPi sensitivity in BRCA2-deficient cells.

55 citations

humanCRISPR screen

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Molecular BiologyNature CommunicationsPeer-reviewedMay 1, 2020

PCNA ubiquitination protects stalled replication forks from DNA2-mediated degradation by regulating Okazaki fragment maturation and chromatin assembly

Tanay Thakar, Wendy Leung, Claudia M. Nicolae…·George‐Lucian Moldovan

This study shows that PCNA ubiquitination protects stalled replication forks from DNA2-mediated degradation by ensuring efficient Okazaki fragment maturation and chromatin assembly, enhancing resistance to PARP-inhibitors in BRCA-deficient cells.

136 citationstop 3%

humanexperimental assay

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