Author

Hong‐Gang Wang

Pennsylvania State UniversityORCID 0000-0003-0551-0571Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:CRISPR screen· 1 Organism:human· 1 Assay:imaging· 1 Organism:mouse· 1 Research Focus:perturbation response prediction· 1 Research Focus:spatial domain detection· 1

Frequent Co-Authors

Anastasia HaleiD· 1 shared Anchal SharmaiD· 1 shared Ashna DhoonmooniD· 1 shared Claudia M. NicolaeiD· 1 shared Emily M. SchleicheriD· 1 shared Geoffrey S. PittiD· 1 shared George‐Lucian MoldovaniD· 1 shared Hui LiuiD· 1 shared

Activity by Year

2020-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperMolecular Biology

Anastasia HaleORCID

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2 papers

Recent·Most cited

Nanometer-Scale Imaging of Compartment-Specific Localization and Dynamics of Voltage-Gated Sodium Channels

Hui Liu, Hong‐Gang Wang, Geoffrey S. Pitt, Zhe J. Liu

This study develops optical imaging methods to analyze subcellular localization and dynamics of voltage-gated sodium channels in neurons, revealing developmental regulation and a novel trafficking pathway.

Journal of Neuroscience · Jun 7, 2022Peer-reviewedNeuroscience

Identification of regulators of poly-ADP-ribose polymerase (PARP) inhibitor response through complementary CRISPR knockout and activation screens

Kristen E. Clements, Emily M. Schleicher, Tanay Thakar, Anastasia Hale, Ashna Dhoonmoon, Nathanial J. Tolman, Anchal Sharma, Xinwen Liang, Yuka Imamura Kawasawa, Claudia M. Nicolae, Hong‐Gang Wang, Subhajyoti De, George‐Lucian Moldovan

This study identifies genetic regulators of PARP inhibitor response using CRISPR screens, revealing TIP60 as a key factor that reverses PARPi sensitivity in BRCA2-deficient cells.

Nature Communications · Nov 30, 2020Peer-reviewedMolecular Biology