Author

Anastasia Hale

Pennsylvania State UniversityORCID 0000-0002-7955-7316Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Assay:CRISPR screen· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:perturbation response prediction· 2

Frequent Co-Authors

Claudia M. NicolaeiD· 2 shared George‐Lucian MoldovaniD· 2 shared Alexandra NusawardhanaiD· 1 shared Anchal SharmaiD· 1 shared Ashna DhoonmooniD· 1 shared Emily M. SchleicheriD· 1 shared Hong‐Gang WangiD· 1 shared Joshua Straka· 1 shared

Activity by Year

2020-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersGenetics

Claudia M. NicolaeORCID

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2 papers

Recent·Most cited

Genome-wide CRISPR screens identify DNA repair and R-loop suppression as regulators of the cellular sensitivity to environmentally relevant Bisphenol A exposure

Anastasia Hale, Alexandra Nusawardhana, Joshua Straka, Claudia M. Nicolae, George‐Lucian Moldovan

bioRxiv · Apr 15, 2026 · PreprintGenetics

Identification of regulators of poly-ADP-ribose polymerase (PARP) inhibitor response through complementary CRISPR knockout and activation screens

Kristen E. Clements, Emily M. Schleicher, Tanay Thakar, Anastasia Hale, Ashna Dhoonmoon, Nathanial J. Tolman, Anchal Sharma, Xinwen Liang, Yuka Imamura Kawasawa, Claudia M. Nicolae, Hong‐Gang Wang, Subhajyoti De, George‐Lucian Moldovan

This study identifies genetic regulators of PARP inhibitor response using CRISPR screens, revealing TIP60 as a key factor that reverses PARPi sensitivity in BRCA2-deficient cells.

Nature Communications · Nov 30, 2020Peer-reviewedMolecular Biology