Claudia M. Nicolae

The paper identifies the HELQ-RAD52 axis as a regulator of cisplatin-induced ssDNA gap processing through CRISPR screens in human cells.

This study identifies lagging strand ssDNA gaps as drivers of fork degradation in BRCA-deficient cells by inhibiting PCNA unloading and CAF-1-dependent nucleosome assembly.

This study identifies genetic regulators of PARP inhibitor response using CRISPR screens, revealing TIP60 as a key factor that reverses PARPi sensitivity in BRCA2-deficient cells.

This study shows that PCNA ubiquitination protects stalled replication forks from DNA2-mediated degradation by ensuring efficient Okazaki fragment maturation and chromatin assembly, enhancing resistance to PARP-inhibitors in BRCA-deficient cells.