Cancer BiologybioRxivPreprint
Redirecting resistance evolution in BRAFV600 melanoma by inhibition of the peroxiredoxin-thioredoxin system
Stefanie Egetemaier, Heike Chauvistré, Renáta Váraljai…·Alexander Roesch
This study identifies KDM5B's role in regulating the PRDX/TXN ROS detoxification system in melanoma DTPs, showing that PRDX inhibition increases ROS vulnerability and delays resistance to MAPK inhibition.
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