Laurel E. Hind

Anti-inflammatory macrophages limit endothelial inflammation and restrict neutrophil recruitment through Gas6/AXL signaling

The paper shows anti-inflammatory macrophages reduce endothelial inflammation and neutrophil recruitment via Gas6/AXL signaling in a 3D inflammation-on-a-chip model.

Endothelial Heterogeneity Across Vascular Beds Impacts Inflammatory Signaling and Neutrophil Adhesion

This study examines how endothelial cell heterogeneity across vascular beds affects inflammatory signaling and neutrophil adhesion through experimental analysis and statistical modeling.

Fibronectin and laminin differentially affect the inflammatory environment in microphysiological systems

This study investigates how fibronectin and laminin affect the inflammatory environment in 3D engineered constructs using an inflammation-on-a-chip device.

Interleukin-6 Concentration Regulates the Neutrophil Response to Diverse Bacteria

This study shows that varying concentrations of IL-6 affect neutrophil responses to different bacteria, with higher concentrations reducing migration and lower concentrations having pathogen-specific effects.

Synovial fibroblasts support vascular function in an acute injury-on-a-chip model

This study develops an injury-on-a-chip model to investigate synovial fibroblasts' role in vascular function during acute inflammation, finding they support vascular health rather than drive disease.

Empowering high-throughput high-content analysis of 3D tumor models: Open-source software for automated non-confocal image analysis

This paper develops open-source software for automated analysis of 3D tumor models using non-confocal microscopy, achieving accurate drug sensitivity measurements and significantly reducing processing time.