Tommaso Ristori

The paper uses computational modeling to show that ALK1 knockout impairs angiogenesis by affecting YAP/TAZ signaling and endothelial phenotypic selection, suggesting YAP/TAZ targeting could restore vascular function in HHT.

This study shows Bmp9 upregulates Lunatic Fringe in endothelial cells, enhancing Notch signaling and regulating angiogenesis dynamics.

This study shows Notch2 drives canonical Notch signaling in smooth muscle differentiation, while Notch3 requires higher doses to activate transcription due to weaker RBPJκ interaction, with implications for artery-specific diseases.