Author

Sandra Loerakker

Eindhoven University of TechnologyORCID 0000-0002-9574-1623Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Developmental Biology· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 2 Approach:experimental assay· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

Tommaso RistoriiD· 2 shared Cecilia SahlgreniD· 1 shared Hesam Hoursan· 1 shared Margot PassieriD· 1 shared Marika SjöqvistiD· 1 shared Noora VirtaneniD· 1 shared Sami ŞanlıdağiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

7 top collaborators · 16 mutual co-author links

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2 shared papersSystems Biology

Tommaso RistoriORCID

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2 papers

Recent·Most cited

Targeting stiffness-dependent YAP/TAZ restores angiogenesis dynamics impaired by ALK1 knockout in silico

Margot Passier, Sandra Loerakker, Tommaso Ristori

The paper uses computational modeling to show that ALK1 knockout impairs angiogenesis by affecting YAP/TAZ signaling and endothelial phenotypic selection, suggesting YAP/TAZ targeting could restore vascular function in HHT.

PLoS Computational Biology · Jul 16, 2026Peer-reviewedSystems Biology

Receptor stoichiometry predicts artery-typical vulnerability to altered Notch signaling during smooth muscle differentiation.

Sami Şanlıdağ, Noora Virtanen, Hesam Hoursan, Tommaso Ristori, Marika Sjöqvist, Sandra Loerakker, Cecilia Sahlgren

This study shows Notch2 drives canonical Notch signaling in smooth muscle differentiation, while Notch3 requires higher doses to activate transcription due to weaker RBPJκ interaction, with implications for artery-specific diseases.

bioRxiv · May 5, 2025 · PreprintDevelopmental Biology