Cecilia Sahlgren

This study shows Jagged1 promotes ECM remodeling in TNBC by enhancing fibroblast activation and TGFβ signaling, suggesting it as a therapeutic target.

This study identifies a non-canonical role for Jagged1 in regulating mechanosensitive kinase activity in endothelial cells under mechanical stress.

This study shows Bmp9 upregulates Lunatic Fringe in endothelial cells, enhancing Notch signaling and regulating angiogenesis dynamics.

The paper identifies Myo1c as a factor interacting with Jag1 in endothelial cells, showing its role in Jag1 trafficking under shear stress.

This study uses phosphoproteomic analysis in zebrafish to show that ErbB inhibitors affect multiple signaling pathways, leading to similar physiological phenotypes.

This study shows Notch2 drives canonical Notch signaling in smooth muscle differentiation, while Notch3 requires higher doses to activate transcription due to weaker RBPJκ interaction, with implications for artery-specific diseases.