Cancer BiologybioRxivPreprint
All-trans retinoic acid induces durable tumor immunity in IDH-mutant gliomas by rescuing transcriptional repression of the CRBP1-retinoic acid axis
Aparna Rao, Xiaoran Zhang, Anthony Richard Cillo…·Nduka Amankulor
This study shows that all-trans retinoic acid (ATRA) improves immune response in IDH-mutant gliomas by restoring the RA pathway, leading to tumor regression in mouse models and a clinical trial for human patients.