All-trans retinoic acid induces durable tumor immunity in IDH-mutant gliomas by rescuing transcriptional repression of the CRBP1-retinoic acid axis
Aparna Rao, Xiaoran Zhang, Anthony Richard Cillo, Jonathan Sussman, Poorva Sandlesh, Antonio Corral Tarbay, Arka N. Mallela, Carly Cardello, Katharine Krueger, Jessica A. Xu, Alex M. Li, Jason Z. Xu, Jonathan Patterson, Ebrar Akca, Angelo Angione, , Nduka Amankulor
This study shows that all-trans retinoic acid (ATRA) improves immune response in IDH-mutant gliomas by restoring the RA pathway, leading to tumor regression in mouse models and a clinical trial for human patients.
bioRxiv · Apr 9, 2024 · PreprintCancer Biology