Vaccines combining slow delivery and follicle targeting of antigens increase germinal center B cell clonal diversity and clonal expansion
Kristen A. Rodrigues, Yiming J. Zhang, Jonathan H. Lam, Aereas Aung, Duncan M. Morgan, Anna M. Romanov, Laura Maiorino, Parisa Yousefpour, Grace Gibson, Gabriel Ozorowski, Justin R. Gregory, Parastoo Amlashi, Richard Van, Maureen Buckley, Andrew B. Ward, , Darrell J. Irvine
This study shows that combining slow antigen delivery and follicle-targeting adjuvants enhances germinal center B cell diversity and clonal expansion in mice.
Science Translational Medicine · Jun 18, 2025Peer-reviewedImmunology