Kristen A. Rodrigues

Vaccines combining slow delivery and follicle targeting of antigens increase germinal center B cell clonal diversity and clonal expansion

This study shows that combining slow antigen delivery and follicle-targeting adjuvants enhances germinal center B cell diversity and clonal expansion in mice.

Diverse priming outcomes under conditions of very rare precursor B cells

The paper investigates how vaccine antigen delivery and adjuvant selection affect the priming of rare HIV broadly neutralizing antibody-precursor B cells in non-human primates, finding that specific dosing and adjuvant combinations enhance their detection in germinal centers.

Engineered SARS-CoV-2 receptor binding domain improves immunogenicity in mice and elicits protective immunity in hamsters

This paper describes an engineered SARS-CoV-2 RBD variant that shows improved immunogenicity in mice and protective immunity in hamsters.