Author

Paul D. Smith

AstraZeneca (United Kingdom)ORCID 0000-0002-2812-5978Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1

Frequent Co-Authors

Anne Segonds-PichoniD· 1 shared Jonathan M. HouseleyiD· 1 shared Kieron MayiD· 1 shared Prasanna ChannathodiyiliD· 1 shared Simon J. CookiD· 1 shared

Activity by Year

2022-2022 · peak 1/yr

Co-Author Collaboration Network

5 top collaborators · 10 mutual co-author links

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1 shared paperMolecular Biology

Anne Segonds-PichonORCID

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1 paper

Recent·Most cited

Molecular BiologyNAR CancerPeer-reviewedSep 28, 2022

DNA replication during acute MEK inhibition drives acquisition of resistance through amplification of the BRAF oncogene

Prasanna Channathodiyil, Kieron May, Anne Segonds-Pichon…·Jonathan M. Houseley

The paper shows that DNA replication during MEK inhibition drives BRAF amplification and resistance in COLO205 cells, and that blocking cell cycle entry can suppress resistance.

6 citations

humanbulk RNA-seq

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