Author
Babraham InstituteORCID 0000-0002-7307-6976Unclaimed ORCID profile · follow to get notified of new preprints
4 papers
Recent·Most cited
Adhithi R. Raghavan, Kieron May, Vijayalakshmi V. Subramanian…·Andreas Hochwagen
The paper shows that multiple mechanisms suppress meiotic recombination near chromosome ends in yeast, involving both axis protein downregulation and DNA break suppression.
Kieron May, Giuditta Illuzzi, Matthew J. Martin, Jonathan M. Houseley
This study shows that osimertinib treatment leads to a Drug Tolerant Persister state with replication defects, genome instability, and hypersensitivity to DNA repair inhibitors.
Gabriele Picco, Yanhua Rao, Angham Al Saedi…·Mathew J. Garnett
This study identifies on-target WRN mutations as resistance mechanisms in MSI cancer cells to WRN helicase inhibitors and suggests combination therapies to prevent resistance.
Prasanna Channathodiyil, Kieron May, Anne Segonds-Pichon…·Jonathan M. Houseley
The paper shows that DNA replication during MEK inhibition drives BRAF amplification and resistance in COLO205 cells, and that blocking cell cycle entry can suppress resistance.