Investigation of Disease-Relevant Lysine Acetylation Sites in α-Synuclein Enabled by Non-canonical Amino Acid Mutagenesis
Marie Shimogawa, Minghao Li, Grace Shin Hye Park, Jennifer Ramirez, Hudson Lee, Paris R. Watson, Swati Sharma, Zongtao Lin, Chao Peng, Virginia M.-Y. Lee, Benjamin A. Garcia, David W. Christianson, Elizabeth R. Rhoades, David Eliezer, E. James Petersson
This study investigates how acetylation of specific lysine sites in α-synuclein affects aggregation and function, identifying K80 acetylation as a potential therapeutic target.
bioRxiv · Jan 21, 2025 · PreprintBiochemistry