Author

Benjamin A. Garcia

Washington University in St. Louis

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Same name, identified by ORCID

Biology Disciplines

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Biochemistry· 2 Cancer Biology· 1 Genetics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Assay:ChIP-seq· 3 Organism:human· 3 Assay:proteomics· 3 Research Focus:chromatin & epigenetic regulation· 2 Research Focus:drug response / drug discovery· 2 Approach:statistical model· 2 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

Agata L. PatriotisiD· 1 shared Akshata Udyavar· 1 shared Alexandra Stevens· 1 shared Alexey A. SoshneviD· 1 shared Amy Carr· 1 shared Anagha Deshpande· 1 shared Andrew R. NageriD· 1 shared Aniruddha J. DeshpandeiD· 1 shared

Activity by Year

2017-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperGenetics

Agata L. PatriotisORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Disrupting a Convergent Acetylation Circuit Collapses Leukemic Identity Across AML Subtypes

Anagha Deshpande, Cho-Ying Chiang, Marlenne Perales, Neha Niranjan, Neelam Sinha, Darren Finlay, Alexandra Stevens, Emily Zahn, Benjamin A. Garcia, Irmela Jeremias, Mark Wunderlich, Kristen Jensen-Pergakes, Akshata Udyavar, Amy Carr, Andrew R. Nager, , Aniruddha J. Deshpande

This paper identifies an acetylation-dependent circuit controlling SEC integrity in AML, showing that disrupting KAT2A/B leads to broad anti-leukemic effects across subtypes.

bioRxiv · Jul 14, 2026 · PreprintCancer Biology

The conserved N-terminal SANT1-binding domain (SBD) of EZH2 Regulates PRC2 Activity

Agata L. Patriotis, Yadira M. Soto‐Feliciano, Douglas Barrows, Laiba F Khan, Marylène Leboeuf, Peder J. Lund, Matthew R. Marunde, Annaelle Djomo, Michael‐Christopher Keogh, Thomas S. Carroll, Benjamin A. Garcia, Alexey A. Soshnev, C. David Allis

This study investigates how the conserved SBD of EZH2 regulates PRC2 activity, showing its necessity for histone methylation and cancer cell proliferation.

Genes & Development · Feb 9, 2026Peer-reviewedGenetics

Investigation of Disease-Relevant Lysine Acetylation Sites in α-Synuclein Enabled by Non-canonical Amino Acid Mutagenesis

Marie Shimogawa, Minghao Li, Grace Shin Hye Park, Jennifer Ramirez, Hudson Lee, Paris R. Watson, Swati Sharma, Zongtao Lin, Chao Peng, Virginia M.-Y. Lee, Benjamin A. Garcia, David W. Christianson, Elizabeth R. Rhoades, David Eliezer, E. James Petersson

This study investigates how acetylation of specific lysine sites in α-synuclein affects aggregation and function, identifying K80 acetylation as a potential therapeutic target.

bioRxiv · Jan 21, 2025 · PreprintBiochemistry

Synthesis of a eukaryotic chromosome reveals a role for N6-methyladenine in nucleosome organization

Leslie Y. Beh, Galia T. Debelouchina, Kelsi A. Lindblad, Katarzyna Kulej, Elizabeth R. Hutton, John R. Bracht, Robert P. Sebra, Benjamin A. Garcia, Tom W. Muir, Laura F. Landweber

The paper synthesizes Oxytricha trifallax chromosomes to study how N6-methyladenine affects nucleosome organization and interacts with histone modifications.

bioRxiv · Sep 6, 2017 · PreprintBiochemistry