Matthew D. Zdradzinski

The paper shows that KHSRP-mediated decay of axonal Prenyl-Cdc42 mRNA slows nerve regeneration by regulating mRNA stability and transport in response to growth signals.

This study shows PTBP1 is expressed in adult sensory and motor neurons, with increased axonal levels after injury, affecting axon outgrowth and sensation.

This study identifies KHSRP as an axonal RNA-binding protein whose mRNA is locally translated after nerve injury, leading to mRNA destabilization and slowed axon regeneration.

The paper shows that prenyl-Cdc42 mRNA localizes to PNS axons and promotes axon growth through localized translation and prenylation.