James Drew

The non-adrenergic imidazoline-1 receptor protein Nischarin is a key regulator of astrocyte glutamate uptake

This study identifies Nischarin as a regulator of GLT-1 surface expression and function in astrocytes, showing its role in glutamate uptake and neuroprotection.

Control of microglial dynamics by Arp2/3 and the autism and schizophrenia-associated protein Cyfip1

This study identifies the role of Arp2/3 and Cyfip1 in regulating microglial dynamics and suggests their involvement in neuropsychiatric diseases.

AP-4 mediated ATG9A sorting underlies axonal and autophagosome biogenesis defects in a mouse model of AP-4 deficiency syndrome

This study shows that AP-4 deficiency in mice causes axonal and autophagosome biogenesis defects by impairing ATG9A sorting from the trans-Golgi network.

Correct CYFIP1 dosage is essential for synaptic inhibition and the excitatory/inhibitory balance.

This study shows CYFIP1 dosage affects inhibitory synaptic structure and function, impacting the excitatory/inhibitory balance and potentially contributing to neurodevelopmental disorders.