Author
Simons Initiative for the Developing BrainORCID 0000-0002-4652-0234Unclaimed ORCID profile · follow to get notified of new preprints
6 papers
Recent·Most cited
Katherine Bonnycastle, Katharine L. Dobson, E-M. Blumrich…·Michael Alan Cousin
This study shows that a mutation in DNM1 causes epilepsy by disrupting synaptic vesicle endocytosis, and that a drug can reverse these effects in a mouse model.
Christiana Kontaxi, Daniela Ivanova, Elizabeth C. Davenport…·Michael Alan Cousin
This study shows that CDKL5 deficiency impairs synaptic vesicle endocytosis in neurons, highlighting its presynaptic role in epilepsy.
Christopher Small, Callista B. Harper, Anmin Jiang…·Frédéric A. Meunier
The paper shows that SV2A-Syt1 nanoclusters limit dynamin-1 recruitment, thereby controlling the re-entry of Syt1 into recycling synaptic vesicles.
Laura Simões de Oliveira, Heather O’Leary, MS Nawaz…·Peter C. Kind
This study investigates synaptic function in a Cdkl5 KO rat model of CDKL5 deficiency disorder, finding normal NMDA and AMPA receptor function but altered synaptic density and plasticity.
Christopher Small, Callista B. Harper, Christiana Kontaxi…·Frédéric A. Meunier
This study shows that the SV2A-Syt1 interaction forms surface nanoclusters, which regulate their entry into recycling synaptic vesicles.
Elizabeth C. Davenport, Blanka R. Szulc, James Drew…·Josef T. Kittler
This study shows CYFIP1 dosage affects inhibitory synaptic structure and function, impacting the excitatory/inhibitory balance and potentially contributing to neurodevelopmental disorders.