I. Lorena Arancibia‐Cárcamo

This study identifies TRPML1 loss as a cause of lysosomal calcium failure and astrocyte dysfunction in Alzheimer's Disease, showing that restoring TRPML1 can prevent disease progression.

This study identifies glycogen metabolism as a key regulator of microglial function in Alzheimer's disease, showing that glycogenolysis drives microglial activation and that inhibiting it reduces Abeta uptake and functional impairment.

This study compares two high-resolution spatial transcriptomics platforms in an AD mouse model to characterize the amyloid plaque cell niche and its cellular responses.

This study investigates the role of Miro1 in mitochondrial dynamics of parvalbumin interneurons and shows its impact on neuronal signaling and network synchronization.

This study identifies the role of Arp2/3 and Cyfip1 in regulating microglial dynamics and suggests their involvement in neuropsychiatric diseases.