Author

Flavie Lesept

University College LondonORCID 0000-0002-7398-9652Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Approach:deep learning· 1 Research Focus:dimensionality reduction· 1 Organism:human· 1 Assay:imaging· 1

Frequent Co-Authors

Josef T. KittleriD· 3 shared Aleksandar P. IvanoviD· 1 shared Amanda J. FoustiD· 1 shared Annie SahotaiD· 1 shared Binoy Paulose NadappuramiD· 1 shared Carmel L. HoweiD· 1 shared Davor IvankoviciD· 1 shared Francesco A. AprileiD· 1 shared

Activity by Year

2019-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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3 shared papersNeuroscience

Josef T. KittlerORCID

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3 papers

Recent·Most cited

Tracking gene expression of single mitochondria in live neurons using nanotweezers

Annie Sahota, Binoy Paulose Nadappuram, Siân C. Allerton, Flavie Lesept, Jack H. Howden, Suzanne Claxton, Yaxian Liu, Francesco A. Aprile, Josef T. Kittler, Michael J. Devine, Aleksandar P. Ivanov, Joshua B. Edel

The paper tracks mitochondrial gene expression in live neurons using nanotweezers and finds downregulation of MT-ND1 and MT-ATP6 after exposure to α-synuclein aggregates.

Journal of the American Chemical Society · Jun 9, 2026Peer-reviewedNeuroscience

Physics-based Deep Learning for Imaging Neuronal Activity via Two-photon and Light Field Microscopy

Herman Verinaz-Jadan, Carmel L. Howe, Pingfan Song, Flavie Lesept, Josef T. Kittler, Amanda J. Foust, Pier Luigi Dragotti

This paper develops a physics-driven deep learning method to reconstruct neuronal activity from light field microscopy images, outperforming existing methods in quality and speed.

IEEE Transactions on Computational Imaging · Jan 1, 2023Peer-reviewedNeuroscience

AP-4 mediated ATG9A sorting underlies axonal and autophagosome biogenesis defects in a mouse model of AP-4 deficiency syndrome

Davor Ivankovic, James Drew, Flavie Lesept, Ian J. White, Guillermo López‐Doménech, Sharon A. Tooze, Josef T. Kittler

This study shows that AP-4 deficiency in mice causes axonal and autophagosome biogenesis defects by impairing ATG9A sorting from the trans-Golgi network.

Autophagy · May 29, 2019Peer-reviewedNeuroscience