GenomicsGenome biologyPeer-reviewed
Deep Insertion, Deletion, and Missense Mutation Libraries for Exploring Protein Variation in Evolution, Disease, and Biology
Christian B. Macdonald, David M. Nedrud, Patrick Rockefeller Grimes…·Willow Coyote‐Maestas
The paper introduces DIMPLE, a method for generating indel and missense mutation libraries, and demonstrates its application in studying the impact of mutations on protein function.
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