Daniel Schmidt

This paper develops AAV-m5, a nanobody-functionalized AAV vector that targets neurons via mGluR5, achieving efficient and specific transduction in the CNS without relying on promoters.

This paper reports engineered AAV capsids that directly package proteins, demonstrating efficient delivery and activity of packaged proteins.

This study shows that swapping nanobodies at specific AAV capsid hotspots enables precise tropism switching for targeted gene therapy without extensive optimization.

This paper describes a split Staphylococcus aureus prime editor delivered by dual AAVs, demonstrating in vitro editing capacity despite lower-than-ideal efficiency.

The paper develops an all-optical phenotypic screening system for cultured primary neurons to assess optogenetic actuators efficiently.