Author

Donovan Trinidad

University of California, San FranciscoORCID 0000-0002-1439-9927Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Genomics· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Organism:mouse· 1 Research Focus:perturbation response prediction· 1 Research Focus:protein design· 1

Frequent Co-Authors

Christian B. MacdonaldiD· 3 shared Willow Coyote‐MaestasiD· 3 shared James S. FraseriD· 2 shared Patrick Rockefeller GrimesiD· 2 shared Aashish ManglikiD· 1 shared Christian B. BillesbølleiD· 1 shared Darko MitroviciD· 1 shared David M. NedrudiD· 1 shared

Activity by Year

2023-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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3 shared papersBiochemistry

Christian B. MacdonaldORCID

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3 papers

Recent·Most cited

BiochemistryCellPeer-reviewedJan 2, 2025

Molecular basis of proton-sensing by G protein-coupled receptors

Matthew K. Howard, Nicholas Hoppe, Xi‐Ping Huang…·Aashish Manglik

The paper identifies proton-sensing mechanisms in GPCRs using cryo-EM and deep mutational scanning, revealing a network of residues rather than a single site for proton recognition.

84 citationstop 1%

humanstructural biology

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MicrobiologybioRxivPreprintAug 23, 2024

Deep mutational scanning of EccD3 reveals the molecular basis of its essentiality in the mycobacterium ESX secretion system

Donovan Trinidad, Christian B. Macdonald, Oren S. Rosenberg…·Willow Coyote‐Maestas

This study performs a deep mutational scan on EccD3 in M. smegmatis to understand its role in the ESX-3 secretion system and its importance for mycobacterial survival.

1 citation

mouseexperimental assay

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GenomicsGenome biologyPeer-reviewedFeb 24, 2023

Deep Insertion, Deletion, and Missense Mutation Libraries for Exploring Protein Variation in Evolution, Disease, and Biology

Christian B. Macdonald, David M. Nedrud, Patrick Rockefeller Grimes…·Willow Coyote‐Maestas

The paper introduces DIMPLE, a method for generating indel and missense mutation libraries, and demonstrates its application in studying the impact of mutations on protein function.

68 citationstop 1%

protein sequenceexperimental assay

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