A fluorescent probe enables the discovery of improved antagonists targeting the intracellular allosteric site of the chemokine receptor CCR7
Silas L. Wurnig, Max E. Huber, Corinna Weiler, Hanna Baltrukevich, Nicole Merten, Isabel Stötzel, Teresa Steffen, Yinshui Chang, René H. L. Klammer, Dirk Baumjohann, Eva Kiermaier, Peter Kolb, Evi Kostenis, Matthias Schiedel, Finn K. Hansen
This study develops a fluorescent ligand to identify improved antagonists targeting the intracellular allosteric site of CCR7, showing their effectiveness in both recombinant and endogenous settings.
Journal of Medicinal Chemistry · Feb 12, 2025Peer-reviewedPharmacology & Toxicology